The Naipaul House is situated in St. James in the City of Port of Spain comprising 213.7 square metres, bounded on the north by No. 49 Western Main Road, on the south by No. 24 Nepaul Street, on the east by No. 47 Western Main Road, and on the west by Nepaul Street.

 This house was the home of writer (for the Trinidad Guardian in 1929) Seepersad Naipaul and his wife Droapatie (Capildeo), and their sons Nobel Laureate, Sir V. S. Naipaul and the novelist Shiva Naipaul between 1946 and 1995. In 2002 it was purchased by the Government of Trinidad and Tobago and restored.  The house is nominated for its association with the well-known Naipaul family. Sir Vidiadhar Surajprasad “Vidia” Naipaul is known for his early novels set in Trinidad and Tobago. He has published more than thirty books, both of fiction and nonfiction, over some fifty years. In 2001 he won the Nobel Prize for literature, the world’s most prestigious and richest literary award.

The house is known as the model for the eponymous house in Naipaul’s 1963 novel A House for Mr Biswas. The Naipaul House is approximately 14 kilometres from Traum House Lodge.